Morphine vs Fentanyl Comparison
Fentanyl exhibits signaling bias with greater arrestin relative to G-protein signaling, as measured by GTPγS binding in cells expressing mouse or human MORs (Schmid et al., 2017). In cell culture experiments, fentanyl promotes robust receptor phosphorylation, beta-arrestin-2 recruitment and receptor internalization but morphine has much weaker effects on these parameters. Perhaps surprising given the agonist … Read more